Hepatitis B Vaccines with Adjuvants

Yes, hepatitis B vaccines can be adjuvanted to boost immune response. In clinical research settings, adjuvants like QS-21 are explored to strengthen both humoral and cellular immunity. QS-21 has been evaluated in hepatitis B vaccine trials and is currently used in five globally approved vaccines, demonstrating its broad immunological effectiveness across infectious disease indications.

QS-21 is a triterpene glycoside saponin (molecular weight 1990 Da) purified from Quillaja saponaria Molina bark via RP-HPLC. It simultaneously stimulates antibody production and cellular immunity (CD4+ and CD8+ T-cell responses), making it one of the most potent adjuvants available. Each gram of QS-21 enables 20,000–40,000 human vaccine doses, supporting large-scale immunization programs.

QS-21 is a key component in five globally approved vaccines: Shingrix (shingles, >95% efficacy), Mosquirix RTS,S and R21/Matrix-M (malaria), Arexvy (RSV), and COVID-19 vaccines. It functions within composite adjuvant systems including AS01, AS02, ALFQ, and Matrix-M, and is under clinical evaluation in over 20 additional vaccine candidates including hepatitis B, HIV, and cancer vaccines.

Yes. QS-21 supplied through VuRoyal Pharmaceutical meets GMP (Good Manufacturing Practice) standards and holds IPEC GMP certification and EXCiPACT certification — Desert King International is the first Chilean company and the only global Quillaja supplier to achieve EXCiPACT status. The excipient has also entered Public Notice Phase I with China's Center for Drug Evaluation as of September 2025.

Desert King International currently produces 5 kg of QS-21 annually with capacity expandable to 10 kg, supporting 200–400 million human vaccine doses per year. Manufacturing facilities are located in Chile, Mexico, and Italy, all GMP-certified. VuRoyal manages the full supply chain from forest-sourced raw materials to final GMP-grade product delivery.

Clinical trial sponsors can procure QS-21 through VuRoyal Pharmaceutical, the exclusive distributor of Desert King International in China and an FDA-registered pharmaceutical wholesaler in the U.S. VuRoyal provides end-to-end services including international procurement, regulatory guidance, import filing, customs clearance, and cold chain pharmaceutical transportation. Contact +86-527-88881019 or qs21@vuroyal.com for pricing and support.